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Lipid-chitosan hybrid nanoparticles for controlled delivery of cisplatin
| Content Provider | Scilit |
|---|---|
| Author | Khan, Muhammad Muzamil Madni, Asadullah Torchilin, Vladimir Filipczak, Nina Pan, Jiayi Tahir, Nayab Shah, Hassan |
| Copyright Year | 2019 |
| Description | Lipid-polymer hybrid nanoparticles (LPHNP) are delivery systems for controlled drug delivery at tumor sites. The superior biocompatible properties of lipids and structural advantages of polymers can be obtained using this system for controlled drug delivery. In this study, cisplatin-loaded lipid-chitosan hybrid nanoparticles were formulated by the single step ionic gelation method based on ionic interaction of positively charged chitosan and negatively charged lipid. Formulations with various chitosan to lipid ratios were investigated to obtain the optimal particle size, encapsulation efficiency, and controlled release pattern. Transmission electron microscope and dynamic light scattering analysis demonstrated a size range of 181–245 nm and a zeta potential range of 20–30 mV. The stability of the formulation was demonstrated by thermal studies. Cytotoxicity and cellular interaction of cisplatin-loaded LPHNP were investigated using in vitro cell-based assays using the A2780 ovarian carcinoma cell line. The pharmacokinetics study in rabbits supported a controlled delivery of cisplatin with enhanced mean residence time and half-life. These studies suggest that cisplatin loaded LPHNP have promise as a platform for controlled delivery of cisplatin in cancer therapy. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/10717544.2019.1642420?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711028/pdf |
| Ending Page | 772 |
| Page Count | 8 |
| Starting Page | 765 |
| ISSN | 10717544 |
| e-ISSN | 15210464 |
| DOI | 10.1080/10717544.2019.1642420 |
| Journal | Drug delivery |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Drug Delivery Pharmacology and Pharmacy Cisplatin Lipid-polymer Hybrid Nanoparticles Chitosan Controlled Release Ovarian Cancer Pharmacokinetics |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Pharmaceutical Science |
