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An Update for the Clinician on Biologics for the Treatment of Psoriatic Arthritis
| Content Provider | Scilit |
|---|---|
| Author | D'Antonio, Arianna Chimenti, Maria Sole Conigliaro, Paola Ferrigno, Sara Vendola, Andrea Ferraioli, Mario Triggianese, Paola Costa, Luisa Caso, Francesco Perricone, Roberto |
| Copyright Year | 2020 |
| Description | Abstract: Psoriatic arthritis (PsA) is a chronic inflammatory arthropathy typically associated with psoriasis (PsO). The pathogenesis is strictly related to the association among the presence of genetic risk alleles and innate and acquired immune response with dramatic consequences on bone remodeling. Clinically, PsA patients may present heterogenicity of articular and periarticular manifestations that may be associated with the presence of comorbidities making treatment decision challenging in patients management. The identification of patient-targeted therapies is still a critical issue. Actually, several biological and synthetic drugs are promising in terms of efficacy and safety profile. National and international treatment recommendations support clinicians in the decision of the best treatment, although they may have limits basically related to updates and different outcomes included in the clinical studies evaluated. The aim of this narrative review is therefore to give guidance for clinicians for PsA patients treatment. For this purpose, we evaluated evidence on biological therapies efficacy used for PsA treatment. Specifically, we reviewed data on biological therapies, Janus kinases (JAK) inhibitors, and drugs with a new mechanism of action that are part of the treatment pipeline. The concept of “switching” and “swapping” is also described, as well as data concerning special populations such as pregnant women and elderly patients. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7445514/pdf https://www.dovepress.com/getfile.php?fileID=60776 |
| Ending Page | 75 |
| Page Count | 23 |
| Starting Page | 53 |
| ISSN | 11775475 |
| e-ISSN | 11775475 |
| DOI | 10.2147/btt.s260754 |
| Journal | Biologics: Targets and Therapy |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-08-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Biologics: Targets and Therapy Rheumatology Jak-inhibitors Tnf-inhibitors Biological Therapies Phosphodiesterase-4 Psoriatic Arthritis Tofacitinib Tsdmards |
| Content Type | Text |
| Resource Type | Article |
| Subject | Immunology and Allergy Gastroenterology Pharmacology (medical) Rheumatology Oncology |
