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Prognostic significance of a novel indicator (PSApostd3/PSApre) for PSA recurrence in patients after radical prostatectomy
| Content Provider | Scilit |
|---|---|
| Author | Zhou, Zhien Xu, Yinyan Li, Qianyue Yan, Weigang Zhou, Yi Zheng, Zhibo Li, Hanzhong Ji, Zhigang |
| Copyright Year | 2019 |
| Description | Purpose: Radical prostatectomy (RP) is a common treatment for prostate cancer, but a fraction of patients may experience PSA recurrence after surgery, manifesting as an elevation in prostate specific antigen (PSA). Vast literature has reported different prognostic factors for PSA recurrence without reaching a consensus. This retrospective study investigated the efficacy of a new indicator in predicting PSA recurrence in patients after RP. Patients and methods: From October 2000 to December 2015, 102 PCa patients who underwent laparoscopic prostatectomy in the Urology Department of Peking Union Medical College Hospital were analyzed. We calculated $PSA_{postd3}/PSA_{pre}$, defined as the ratio of the PSA on day 3 postop as the numerator and the pre-operative PSA as the denominator, in these patients to represent PSA decrement after surgery, and investigated its relationship with PSA recurrence during follow-up. Results: The receiver operating characteristic (ROC) curve of $PSA_{postd3}/PSA_{pre}$ derived a cut-off at 0.453 (sensitivity=0.704, specificity=0.853, P<0.0001), suggesting an increased risk of PSA recurrence in patients whose PSA on day 3 postop did not decrease to approximately half of their preoperative levels. Among several factors, $PSA_{postd3}/PSA_{pre}$ (P<0.0001), pathological T stage (P=0.042) and Gleason Grade (P=0.021) were determined to be significantly associated with PSA recurrence by Fisher's exact test, while only $PSA_{postd3}/PSA_{pre}$ (P<0.001) was significantly related to PSA recurrence-free survival (PRFS) by multivariate logistic regression analysis. Conclusion: These results imply that $PSA_{postd3}/PSA_{pre}$ could provide substantial information for PSA recurrence prediction in patients after RP. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601339/pdf https://www.dovepress.com/getfile.php?fileID=50713 |
| Ending Page | 5783 |
| Page Count | 7 |
| Starting Page | 5777 |
| ISSN | 11791322 |
| DOI | 10.2147/cmar.s197521 |
| Journal | Cancer Management and Research |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Management and Research Oncology Prognosis Prostate Cancer Prostate-specific Antigen |
| Content Type | Text |
| Resource Type | Article |
| Subject | Oncology |
