NDLI: Electrospun chitosan-graft-poly (ε-caprolactone)/poly (ε-caprolactone) nanofibrous scaffolds for retinal tissue engineering

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Electrospun chitosan-graft-poly (ε-caprolactone)/poly (ε-caprolactone) nanofibrous scaffolds for retinal tissue engineering

Content Provider	Scilit
Author	Gu, Jake Xia, Jing Fan, Xianqun Chen, Ping Zhou, Xiaojian Huang, Jin Yu, Jiahui Gu, Ping
Copyright Year	2011
Description	Abstract: A promising therapy for retinal diseases is to employ biodegradable scaffolds to deliver retinal progenitor cells (RPCs) for repairing damaged or diseased retinal tissue. In the present study, cationic chitosan-graft-poly(ε-caprolactone)/polycaprolactone (CS-PCL/PCL) hybrid scaffolds were successfully prepared by electrospinning. Characterization of the obtained nanofibrous scaffolds indicated that zeta-potential, fiber diameter, and the content of amino groups on their surface were closely correlated with the amount of CS-PCL in CS-PCL/PCL scaffolds. To assess the cell–scaffold interaction, mice RPCs (mRPCs) were cultured on the electrospun scaffolds for 7 days. In-vitro proliferation assays revealed that mRPCs proliferated faster on the CS-PCL/PCL (20/80) scaffolds than the other electrospun scaffolds. Scanning electron microscopy and the real-time quantitative polymerase chain reaction results showed that mRPCs grown on CS-PCL/PCL (20/80) scaffolds were more likely to differentiate towards retinal neurons than those on PCL scaffolds. Taken together, these results suggest that CS-PCL/PCL(20/80) scaffolds have potential application in retinal tissue engineering.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3075910/pdf https://www.dovepress.com/getfile.php?fileID=8965
Ending Page	461
Page Count	9
Starting Page	453
e-ISSN	11782013
DOI	10.2147/IJN.S17057
Journal	International Journal of Nanomedicine
Volume Number	6
Language	English
Publisher	Informa UK Limited
Publisher Date	2011-02-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Nanomedicine Biomaterials Differentiation Electrospun Proliferation Retinal Progenitor Cells Tissue Engineering
Content Type	Text
Resource Type	Article

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