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Autophagic degradation of nuclear components in mammalian cells
| Content Provider | Scilit |
|---|---|
| Author | Park, Young-Eun Hayashi, Yukiko K. Bonne, Gisèle Arimura, Takuro Noguchi, Satoru Nonaka, Ikuya Nishino, Ichizo |
| Copyright Year | 2009 |
| Description | Autophagy is an evolutionally conserved intracellular mechanism for the degradation of organelles and proteins. Here we demonstrate the presence of perinuclear autophagosomes/autolysosomes containing nuclear components in nuclear envelopathies caused by mutations in the genes encoding A-type lamins (LMNA) and emerin (EMD). These autophagosomes/autolysosomes were sometimes bigger than nucleus. The autophagic nature is further supported by up-regulation of LC3-II in $Lmna^{H222P/H222P}$ fibroblasts. In addition, inhibition of autophagy led to the accumulation of nuclear abnormalities and reduced cell viability, highly suggesting a beneficial role of autophagy, at least in these cells. Similar giant autophagosomes/autolysosomes were seen even in wild-type cells, albeit rarely, implying that this “nucleophagy” is not confined to the diseased condition, but may be seen even in physiologic conditions to clean up nuclear wastes produced by nuclear damage. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/auto.8901?needAccess=true |
| Ending Page | 804 |
| Page Count | 10 |
| Starting Page | 795 |
| ISSN | 15548627 |
| e-ISSN | 15548635 |
| DOI | 10.4161/auto.8901 |
| Journal | Autophagy |
| Issue Number | 6 |
| Volume Number | 5 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-08-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Autophagy Cell Biology Autophagy Nuclear Components Viability Degradation Proteins Autophagosomes/autolysosomes Autophagic Nuclear Wastes Produced Cells |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
