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Down-regulation of LRIG2 expression by RNA interference inhibits glioblastoma cell (GL15) growth, causes cell cycle redistribution, increases cell apoptosis and enhances cell adhesion and invasion in vitro
| Content Provider | Scilit |
|---|---|
| Author | Wang, Baofeng Han, Lin Chen, Rudong Cai, Mingjun Han, Fuxin Lei, Ting Guo, Dong-Sheng |
| Copyright Year | 2009 |
| Description | The leucine-rich and immunoglobulin-like domains (LRIG) gene family contains LRIG1, 2 and 3. LRIG1 is a negative regulator of EGFR, but little is known about the function of LRIG2. To determine the role of LRIG2 in the progression of glioma, we performed RNA interference-mediated knockdown of LRIG2 in a human glioma cell line (GL15). Down-regulation of LRIG2 expression resulted in: rapid EGF-mediated loss of EGFR; decreased proliferation; G0/G1 arrest; increased spontaneous apoptosis; enhanced cell adhesion and increased invasion capability of GL15 cells in vitro. These findings indicate that LRIG2 possesses distinct functions compared with LRIG1 and validate the attractiveness of LRIG2 as a target in glioma therapy. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cbt.8.11.8375?needAccess=true |
| Ending Page | 1023 |
| Page Count | 6 |
| Starting Page | 1018 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.8.11.8375 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 11 |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2009-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Apoptosis Functions Gl15 Lrig2 Vitro Regulation Glioma Lrig1 Invasion Interference |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
