Loading...
Please wait, while we are loading the content...
Similar Documents
Inhibition of Stat3 activity by YC-1 enhances chemo-sensitivity in hepatocellular carcinoma
| Content Provider | Scilit |
|---|---|
| Author | Lau, Chi Keung Yang, Zhen Fan Lam, Shuk Pik Lam, Chi Tat Ngai, Patricia Tam, Ka Ho Poon, Ronnie Tung-Ping Fan, Sheung-Tat |
| Copyright Year | 2007 |
| Description | The present study investigated the effect of YC-1, a novel anti-cancer agent, on the chemo-sensitivity of hepatocellular carcinoma (HCC). YC-1 was administered with chemo-cytotoxic drug, cisplatin, both in vitro and in vivo. YC-1 alone down-regulated the expression of phosphorylated form of signal transducers and activators of transcription 3 (P-Stat3[705]), a key mediator in chemo-resistance. When combined with cisplatin, YC-1 further promoted tumor cell apoptosis, decreased the expression of P-Stat3(705), Bcl-xL, CyclinD1 and survivin, and induced the cleavage of caspase 9 and PARP. Over-expression of Stat3 reversed YC-1 induced cell death. YC-1 inhibited Stat3 activity by enhancing the polyubiquitination of P-Stat3(705) induced by cisplatin. In the in vivo setting, YC-1 combined with cisplatin remarkably suppressed tumor growth in a HCC xenograft model, and this effect was also accompanied by YC-1 mediated down-regulation of P-Stat3(705), Bcl-xL, Cyclin D1 and survivin, and induction of cleaved caspase 9 and PARP in the tumor tissues. In conclusion, the present study demonstrated a novel anti-cancer effect of YC-1 in enhancing chemo-sensitivity of HCC cells to cisplatin through a Stat3 dependent manner. This finding provides insight into design of a new therapeutic strategy to improve efficacy of chemotherapy in HCC patients. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cbt.6.12.4970?needAccess=true |
| Ending Page | 1907 |
| Page Count | 8 |
| Starting Page | 1900 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.6.12.4970 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 12 |
| Volume Number | 6 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2007-12-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Cell Death Chemo Stat3 Apoptosis Cisplatin Phosphorylated Novel Anti Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
