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Effectiveness and safety of cyclophosphamide or tacrolimus therapy for idiopathic membranous nephropathy
| Content Provider | Scilit |
|---|---|
| Author | Zou, Honghong Jiang, Fang Xu, Gaosi |
| Copyright Year | 2019 |
| Description | Background: Guidelines recommend combined therapy of glucocorticoid and cyclophosphamide (CYC) for patients with idiopathic membranous nephropathy (IMN), while it is associated with severe adverse effects. We conducted a retrospective study to evaluate the effectiveness and safety of glucocorticoid plus tacrolimus (TAC) for IMN. Methods: Two hundred and three kidney-biopsy-proven IMN patients were enrolled in this study. One group (n = 142) received glucocorticoid combined with intravenous CYC (750 $mg/m^{2}$ body surface) and the other group (n = 61) received glucocorticoid combined with oral TAC (target blood concentration of 4–8 ng/mL). The primary outcomes were achievement of remission and incidence of adverse events. The secondary end points included relapse rates, 24 h urinary protein (UP), serum albumin, serum creatinine and estimated glomerular filtration rate. Results: Over the 18-month observation period, the study suggested that the remission rates at the first 3 months were significantly higher in TAC group than in CYC group (72.1% versus 54.9%, p < .05). Although the cumulative incidence of serious and non-serious adverse events was not different significantly between the two groups, the incidence after first 3 months was lower in TAC group. 24hUP and serum albumin improved in TAC group more than the CYC group (p < .05) over the observed period. Conclusion: Because of its short-term effectiveness and long-term safety profile, glucocorticoid plus TAC might be a better option for IMN. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/0886022X.2019.1637758?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6711082/pdf |
| Ending Page | 681 |
| Page Count | 9 |
| Starting Page | 673 |
| ISSN | 0886022X |
| e-ISSN | 15256049 |
| DOI | 10.1080/0886022x.2019.1637758 |
| Journal | Renal Failure |
| Issue Number | 1 |
| Volume Number | 41 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Renal Failure Medical Laboratory Technology Idiopathic Membranous Nephropathy Tacrolimus Cyclophosphamide Retrospective Study Effectiveness |
| Content Type | Text |
| Resource Type | Article |
| Subject | Critical Care and Intensive Care Medicine Nephrology |
