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Decrease of Topoisomerase I Activity in the Testes of Infertile Men with Varicocele
| Content Provider | Scilit |
|---|---|
| Author | Fujisawa, M. Yoshida, S. Matsumoto, O. Kojima, K. Kamidono, S. |
| Copyright Year | 1988 |
| Description | Topoisomerase I, which is involved in DNA metabolism, was measured in the testes of 37 infertile men with varicocele, using a minute amount of testicular biopsy specimen. In 38% of infertile men topoisomerase I activity was lower than that of normal men. Forty-six percent of patients with high grade varicocele (grade III) showed reduced topoisomerase I activity, while only 26% of patients with low grade varicocele (grades I and II) showed reduced levels of topoisomerase I. Johnsen's score of the patients with low topoisomerase I activity was lower than that of patients with normal levels of topoisomerase I. The decrease of topoisomerase I activity may be correlated with at least some fraction of hypospermatogenesis associated with varicocele. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/01485018808986732 |
| Ending Page | 50 |
| Page Count | 6 |
| Starting Page | 45 |
| ISSN | 01485016 |
| e-ISSN | 15210375 |
| DOI | 10.3109/01485018808986732 |
| Journal | Archives of andrology |
| Issue Number | 2 |
| Volume Number | 21 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1988-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Archives of Andrology Andrology Topoisomerase I Infertile Men Varicocele Enzymes |
| Content Type | Text |
| Resource Type | Article |
| Subject | Endocrinology |
