NDLI: Development of a New Controlled Release Theophylline Tablet: In Vitro and in Vivo Studies

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Development of a New Controlled Release Theophylline Tablet: In Vitro and in Vivo Studies

Content Provider	Scilit
Author	Georgarakis, M. Panagopoulou, A. Hatzipantou, P. Iliopoulos, Th. Kondylis, M. Grekas, D.
Copyright Year	1990
Description	Five formulations of controlled release theophylline tablets, specially shaped to a multi scored approximately rectangular structure, manually dividable accurately and conveniently into bisectional or trisectional subdosage units were prepared, using ethyl cellulose/hydroxypropylcellulose and Eudragit RL. The influence of two parameters (fillers, granulation) on the dissolution rate of all tablets was studied. It was found that granulation yields greater retardation in dissolution rate, in comparison to direct compression. No significant differences were found among the fillers used, concerning the dissolution rate.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639049009114888
Ending Page	329
Page Count	15
Starting Page	315
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049009114888
Journal	Drug Development and Industrial Pharmacy
Issue Number	2
Volume Number	16
Language	English
Publisher	Informa UK Limited
Publisher Date	1990-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Anesthesiology Controlled Release
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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