NDLI: Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death

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Antibodies to P-selectin glycoprotein ligand-1 block dendritic cell-mediated enterovirus 71 transmission and prevent virus-induced cells death

Content Provider	Scilit
Author	Ren, Xiao-Xin Li, Chuan Xiong, Si-Dong Huang, Zhong Wang, Jian-Hua Wang, Hai-Bo
Copyright Year	2015
Description	P-selectin glycoprotein ligand-1 (PSGL-1) has been proved to serve as the functional receptor for enterovirus 71 (EV71). We found the abundant expression of PSGL-1 on monocyte-derived dendritic cells (MDDCs). However, we have previously demonstrated that MDDCs did not support efficient replication of EV71. Dendritic cells (DCs) have been described to be subverted by various viruses including EV71 for viral dissemination, we thus explore the potential contribution of PSGL-1 on DC-mediated EV71 transmission. We found that the cell-surface-expressing PSGL-1 on MDDCs mediated EV71 binding, and intriguingly, these loaded-viruses on MDDCs could be transferred to encountered target cells; Prior-treatment with PSGL-1 antibodies or interference with PSGL-1 expression diminished MDDC-mediated EV71 transfer and rescued virus-induced cell death. Our data uncover a novel role of PSGL-1 in DC-mediated EV71 spread, and provide an insight into blocking primary EV71 infection.
Related Links	https://www.tandfonline.com/doi/pdf/10.1080/21505594.2015.1094605?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4826143/pdf
Ending Page	808
Page Count	7
Starting Page	802
ISSN	21505594
e-ISSN	21505608
DOI	10.1080/21505594.2015.1094605
Journal	Virulence
Issue Number	8
Volume Number	6
Language	English
Publisher	Informa UK Limited
Publisher Date	2015-11-11
Access Restriction	Open
Subject Keyword	Journal: Virulence Virology Dendritic Cell Enterovirus 71 Viral Transmission P-selectin Glycoprotein Ligand-1
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology Immunology Microbiology Microbiology (medical)

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