NDLI: Cigarette smoke-induced RANKL expression enhances MMP-9 production by alveolar macrophages

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Cigarette smoke-induced RANKL expression enhances MMP-9 production by alveolar macrophages

Content Provider	Scilit
Author	Zhou, Lu Le, Yanqing Tian, Jieyu Yang, Xia Jin, Rong Gai, Xiaoyan Sun, Yongchang
Copyright Year	2018
Description	Cigarette smoke-induced RANKL expression enhances MMP-9 production by alveolar macrophages Lu Zhou,1 Yanqing Le,1 Jieyu Tian,2 Xia Yang,2 Rong Jin,3 Xiaoyan Gai,1 Yongchang Sun1 1Department of Respiratory Medicine, Peking University Third Hospital, Beijing, China; 2Department of Respiratory Medicine, Beijing Tongren Hospital, Capital Medical University, Beijing, China; 3Department of Immunology, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China Background and purpose: Cigarette smoke (CS) induces alveolar destruction through overproduction of proteinases including matrix metalloproteinase (MMP)-9 by alveolar macrophages (AMs). Receptor activator of nuclear factor-κB ligand (RANKL) functions in immune regulation and cytokine secretion; whether it is involved in CS-induced MMP-9 expression is unknown. The purpose of our study was to investigate the expression and functional role of RANKL pathway in MMP-9 production pertaining to the pathogenesis of COPD. Materials and methods: We first localized RANKL and its receptor RANK in the lungs of mice exposed to long-term CS exposure. Next, we studied RANKL and RANK expression under CS extract (CSE) stimulation in vitro. Lastly, we studied the in vitro biological function of RANKL in CS-induced production of MMP-9. Results: Both RANKL and RANK were highly expressed in AMs in CS-exposed mice, but not in the control mice. In vitro, CSE increased the expressions of RANKL and RANK in macrophages. AMs responded to CSE and RANKL stimulation by overexpressing MMP-9, and CSE-induced MMP-9 expression was partly blocked by using monoclonal anti-RANKL antibody. Conclusion: RANKL/RANK pathway mediates CS-induced MMP-9 expression in AMs, suggesting a novel mechanism for CS-associated emphysema. Keywords: COPD, receptor activator of nuclear factor-κB ligand, RANK, alveolar macrophages, MMP-9
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6304243/pdf https://www.dovepress.com/getfile.php?fileID=47099
Ending Page	91
Page Count	11
Starting Page	81
ISSN	11769106
e-ISSN	11782005
DOI	10.2147/copd.s190023
Journal	International journal of chronic obstructive pulmonary disease
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	2018-12-01
Access Restriction	Open
Subject Keyword	Journal: International Journal of Chronic Obstructive Pulmonary Disease Integrative and Complementary Medicine Toxicology Copd Mmp-9 Rank Alveolar Macrophages Receptor Activator of Nuclear Factor-κb Ligand
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine Public Health, Environmental and Occupational Health Health Policy

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