NDLI: Liver-specific microRNA-122: Biogenesis and function

Content Provider	Scilit
Author	Jopling, Catherine
Copyright Year	2012
Description	MicroRNA-122 (miR-122) was one of the first examples of a tissue-specific miRNA. It is highly expressed in liver, where it constitutes 70% of the total miRNA pool. miR-122 expression is specific to the vertebrate lineage, where the sequence of the mature miRNA is completely conserved. miR-122 is a target for extensive study due to its association with cholesterol metabolism and hepatocellular carcinoma, and its important role in promoting hepatitis C virus (HCV) replication. This review will discuss the biogenesis and function of miR-122.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/rna.18827?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3346312/pdf
Ending Page	142
Page Count	6
Starting Page	137
ISSN	15476286
e-ISSN	15558584
DOI	10.4161/rna.18827
Journal	RNA Biology
Issue Number	2
Volume Number	9
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-02-01
Access Restriction	Open
Subject Keyword	Journal: Rna Biology Virology Cat-1 Cholesterol Gld-2 Hepatitis C Virus Microrna Mir-122 Pri-mirna
Content Type	Text
Resource Type	Article
Subject	Cell Biology Molecular Biology

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Liver-specific microRNA-122: Biogenesis and function