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Exosomal microRNA Biomarkers: Emerging Frontiers in Colorectal and Other Human Cancers
| Content Provider | Scilit |
|---|---|
| Author | Tovar-Camargo, Oscar A. Toden, Shusuke Goel, Ajay |
| Copyright Year | 2016 |
| Description | Diagnostic strategies, particularly non-invasive blood-based screening approaches, are gaining increased attention for the early detection and attenuation of mortality associated with colorectal cancer (CRC). However, the majority of current screening approaches are inadequate at replacing the conventional CRC diagnostic procedures. Yet, due to technological advances and better understanding of molecular events underlying human cancer, a new category of biomarkers are on the horizon. Recent evidence indicates that cells release a distinct class of small vesicles called 'exosomes', which contain nucleic acids and proteins that reflect and typify host-cell molecular architecture. Intriguingly, exosomes released from cancer cells have a distinct genetic and epigenetic makeup, which allows them to undertake their tumorigenic function. From a clinical standpoint, these unique cancer-specific fingerprints present in exosomes appear to be detectable in a small amount of blood, making them very attractive substrates for developing cancer biomarkers, particularly noninvasive diagnostic approaches. |
| Related Links | http://europepmc.org/articles/pmc4935983?pdf=render https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4935983/pdf |
| Ending Page | 567 |
| Page Count | 15 |
| Starting Page | 553 |
| ISSN | 14737159 |
| e-ISSN | 17448352 |
| DOI | 10.1586/14737159.2016.1156535 |
| Journal | Expert Review of Molecular Diagnostics |
| Issue Number | 5 |
| Volume Number | 16 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2016-03-16 |
| Access Restriction | Open |
| Subject Keyword | Journal: Expert Review of Molecular Diagnostics Oncology Exosomes Biomarker Cancer Colorectal Cancer Diagnosis Epigenetic Microrna |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology Molecular Medicine Pathology and Forensic Medicine |
