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Outcome of Patients with Relapsed or Refractory Non-Hodgkin's Lymphoma Referred for Autologous Bone Marrow Transplantation
| Content Provider | Scilit |
|---|---|
| Author | Brandwein, Joseph M. Smith, Anne M. Langley, G. Ross Burnell, Margot Sutcliffe, Simon B. Keating, Armand |
| Copyright Year | 1991 |
| Description | Fifty-one patients with relapsed or refractory intermediate- or high-grade non-Hodgkin's lymphoma were referred for autologous bone marrow transplantation (ABMT). The primary criterion for eligibility was sensitivity to conventional-dose salvage chemotherapy. Of 47 patients who received salvage chemotherapy, 30 demonstrated chemotherapy-sensitive disease. Six eligible patients did not undergo ABMT for various reasons. A total of 24 patients underwent ABMT, with etoposide, melphalan ± total body irradiation as the intensive therapy regimen. There was one early treatment-related death and three non-responders. Of the remaining patients, 9 relapsed, while 11 remain in continuous complete remission (CR) at a median follow-up of 21 months after transplant (range 5–37 months). Two patients with chemosensitive disease and bone marrow involvement underwent allogeneic BMT with marrow from HLA-identical siblings. Both are in continuous CR at 6 and 12 months follow-up. Of the 25 patients who did not undergo ABMT, all have died (median survival 5 months). The results indicate that approximately one-half of relapsed or refractory aggressive histology lymphoma patients referred for ABMT eventually undergo transplantation, if chemotherapy-sensitive relapse is the major criterion for eligibility. Approximately 25% of the referred patients may become long-term disease-free survivors with this approach. Reports of marrow transplant series should include all patients referred for ABMT as the denominator for calculating disease-free survival in order to reduce the bias of patient selection. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/10428199109068071 |
| Ending Page | 238 |
| Page Count | 8 |
| Starting Page | 231 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428199109068071 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 4 |
| Volume Number | 4 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1991-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Transplantation Non-hodgkin's Lymphoma Autologous Marrow Transplant Salvage Chemotherapy |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
