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Paclitaxel-Induced FasL-Independent Apoptosis and Slow (Non-Apoptotic) Cell Death
| Content Provider | Scilit |
|---|---|
| Author | Blagosklonny, Mikhail V. Robey, Robert Sheikh, M. Saeed Fojo, Tito |
| Copyright Year | 2002 |
| Description | Microtubule-active drugs, including paclitaxel (Taxol, PTX), cause mitotic arrest, and this can result in apoptosis. A recently study has reported that PTX mediates apoptosis by upregulating FasL in Jurkat and MDA-231 cells. In contrast to the previous report, we found that anti-FasL antibodies failed to inhibit PTX-induced apoptosis in Jurkat cells. In MDA-231 cells, neither FasL nor PTX induced apoptosis. In these cells, PTX caused slow cell death without activation of caspase-3 or -8 or PARP cleavage. Doxorubicin at cytostatic concentrations did not affect FasL-induced apoptosis but inhibited PTX-induced apoptosis in Jurkat cells. Following PTX-induced mitotic arrest Jurkat cells undergo apoptosis, whereas MDA-MB-231 cells exit mitosis and form multinucleated cells which then die in a slower non-apoptotic manner. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cbt.53?needAccess=true |
| Ending Page | 117 |
| Page Count | 5 |
| Starting Page | 113 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.4161/cbt.53 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 2 |
| Volume Number | 1 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2002-03-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Apoptosis Cell Death Ptx Antibodies Jurkat Cells Fasl Induced Mitotic Arrest |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
