NDLI: Lipid peroxidation induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system

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Lipid peroxidation induced by the Cu,Zn-superoxide dismutase and hydrogen peroxide system

Content Provider	Scilit
Author	Kwon, Oh Bin Kang, Jung Hoon
Copyright Year	1999
Description	Cu,Zn‐superoxide dismutase (SOD) can catalyze hydroxyl radical generation using H2O2 as a substrate. Lipid peroxidation induced by the Cu,Zn‐SOD and H2O2 system was investigated. When linoleic acids micelles or phosphatidylcholine liposomes were incubated with Cu,Zn‐SOD and H2O2, lipid peroxidation was gradually increased in a time‐dependent manner. The extent of lipid peroxidation was proportional to Cu,Zn‐SOD and H2O2 concentrations. Hydroxyl radical scavengers and copper chelator inhibited lipid peroxidation induced by the Cu,Zn‐SOD and H2O2 system. These results suggest that lipid peroxidation is mediated by the Cu,Zn‐SOD and H2O2 system via the generation of hydroxyl radicals by a combination of the peroxidative reaction of Cu,Zn‐SOD and the Fenton‐like reaction of free copper released from oxidatively damaged SOD.
Related Links	https://iubmb.onlinelibrary.wiley.com/doi/pdf/10.1080/15216549900201703
Ending Page	653
Page Count	9
Starting Page	645
e-ISSN	15216551
DOI	10.1080/15216549900201703
Journal	IUBMB life
Issue Number	4
Volume Number	47
Language	English
Publisher	Informa UK Limited
Publisher Date	1999-04-01
Access Restriction	Open
Subject Keyword	Journal: Iubmb Life Copper Zinc‐superoxide Dismutase Hydroxyl Radical Lipid Peroxidation Free Copper
Content Type	Text
Resource Type	Article

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