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Long-term cognitive effects of human stem cell transplantation in the irradiated brain
| Content Provider | Scilit |
|---|---|
| Author | Acharya, Munjal M. Martirosian, Vahan Christie, Lori-Ann Limoli, Charles L. |
| Copyright Year | 2014 |
| Description | Purpose: Radiotherapy remains a primary treatment modality for the majority of central nervous system tumors, but frequently leads to debilitating cognitive dysfunction. Given the absence of satisfactory solutions to this serious problem, we have used human stem cell therapies to ameliorate radiation-induced cognitive impairment. Here, past studies have been extended to determine whether engrafted cells provide even longer-term benefits to cognition. Materials and methods: Athymic nude rats were cranially irradiated (10 Gy) and subjected to intrahippocampal transplantation surgery 2 days later. Human embryonic stem cells (hESC) or human neural stem cells (hNSC) were transplanted, and animals were subjected to cognitive testing on a novel place recognition task 8 months later. Results: Grafting of hNSC was found to provide long lasting cognitive benefits over an 8-month post-irradiation interval. At this protracted time, hNSC grafting improved behavioral performance on a novel place recognition task compared to irradiated animals not receiving stem cells. Engrafted hESC previously shown to be beneficial following a similar task, 1 and 4 months after irradiation, were not found to provide cognitive benefits at 8 months. Conclusions: Our findings suggest that hNSC transplantation promotes the long-term recovery of the irradiated brain, where intrahippocampal stem cell grafting helps to preserve cognitive function. |
| Related Links | https://escholarship.org/content/qt3zp1305k/qt3zp1305k.pdf?t=oqf927 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5027837/pdf https://www.tandfonline.com/doi/pdf/10.3109/09553002.2014.927934 |
| Ending Page | 820 |
| Page Count | 5 |
| Starting Page | 816 |
| ISSN | 09553002 |
| e-ISSN | 13623095 |
| DOI | 10.3109/09553002.2014.927934 |
| Journal | International Journal of Radiation Biology |
| Issue Number | 9 |
| Volume Number | 90 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2014-09-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Radiation Biology Cell Tissue Engineering Human Stem Cells Transplantation Radiation Cognition Hippocampus |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging Radiological and Ultrasound Technology |
