In Vitro Approaches for Studying the Inhibition of Drug-Metabolizing Enzymes and Identifying the Drug-Metabolizing Enzymes Responsible for the Metabolism of Drugs (Reaction Phenotyping) with Emphasis on Cytochrome P450

Content Provider	Scilit
Author	Ogilvie, Brian W. Usuki, Etsuko Yerino, Phyllis Parkinson, Andrew
Copyright Year	2019
Description	Victims are those drugs whose clearance is predominantly determined by a single route of elimination, such as metabolism by a single cytochrome P450 (CYP) enzyme. This chapter focuses on in vitro reaction phenotyping and CYP inhibition. A wide range of activity is also observed for many of the CYP enzymes that have a very low incidence of genetic polymorphisms. The primary purpose of evaluating drugs as inhibitors of CYP enzymes in vitro is to determine their perpetrator or precipitant potential before advancing a candidate drug to a late stage of development. An in vitro examination of time-dependent inhibition of the major drugmetabolizing CYP enzymes should be considered essential for drug candidates. Drugs such as tienilic acid not only pose a risk of prolonged inhibition of CYP enzymes, but they can also have wider implications. The use of pooled human liver microsomes for CYP inhibition studies is well documented. Book Name: Drug-Drug Interactions
Related Links	https://content.taylorfrancis.com/books/download?dac=C2008-0-30867-7&isbn=9780429131967&doi=10.1201/9780429131967-7&format=pdf
Ending Page	358
Page Count	128
Starting Page	231
DOI	10.1201/9780429131967-7
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-01-03
Access Restriction	Open
Subject Keyword	Book Name: Drug-drug Interactions Toxicology Vitro Cyp Inhibition Drug Metabolizing Candidates Cytochrome P450 Cyp Enzymes
Content Type	Text
Resource Type	Chapter