NDLI: JSI-124 inhibits glioblastoma multiforme cell proliferation through G2/M cell cycle arrest and apoptosis augmentation

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JSI-124 inhibits glioblastoma multiforme cell proliferation through G2/M cell cycle arrest and apoptosis augmentation

Content Provider	Scilit
Author	Su, Yuhang Li, Gang Zhang, Xulong Gu, Jinhai Zhang, Cai Tian, Zhigang Zhang, Jian
Copyright Year	2008
Description	JSI-124(cucurbitacin I) is a selective inhibitor of Janus kinase /Signal transducer and activator of transcription 3(JAK/STAT3) and has been shown to exert anti-proliferative and anti-tumor properties both in vitro and in vivo. As STAT3 activation has been implicated in the development of glioma, we investigated the therapeutic efficacy of JSI-124 on glioblastoma multiforme (GBM) by interfering with STAT3 pathway. In present study, two GBM cell lines, U251 and A172 cells, were treated with JSI-124. The results showed that the cell growth was inhibited significantly in a dose-and time-dependent manner. Further investigation illustrated that the levels of phosphorylated-STAT3 were decreased in GBM cells treated by JSI-124, concomitant with apoptosis augment and cell cycle arrest. Specially, JSI-124 induced G2/M accumulation via down-regulation of cyclin B1 and cdc2 expression. Together these results suggested that inhibition of STAT3 by JSI-124 is a potential strategy for the development of the new glioblastoma multiforme theraputics.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/cbt.7.8.6263?needAccess=true
Ending Page	1249
Page Count	7
Starting Page	1243
ISSN	15384047
e-ISSN	15558576
DOI	10.4161/cbt.7.8.6263
Journal	Cancer Biology & Therapy
Issue Number	8
Volume Number	7
Language	English
Publisher	Informa UK Limited
Publisher Date	2008-08-01
Access Restriction	Open
Subject Keyword	Journal: Cancer Biology & Therapy Biochemistry and Molecular Biology Apoptosis Phosphorylated Efficacy G2/m Augment Jsi Cell Cycle Arrest
Content Type	Text
Resource Type	Article
Subject	Cancer Research Pharmacology Molecular Medicine Oncology

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