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miR-431-5p alters the epithelial-to-mesenchymal transition markers by targeting UROC28 in hepatoma cells
| Content Provider | Scilit |
|---|---|
| Author | Kong, Qinglei Han, Jianhua Deng, Hong Wu, Feilong Guo, Shaozhong Ye, Zhiqiang |
| Copyright Year | 2018 |
| Description | MiR-431-5p alters the epithelial-to-mesenchymal transition markers by targeting UROC28 in hepatoma cells Qinglei Kong,1,* Jianhua Han,1,* Hong Deng,2 Feilong Wu,1 Shaozhong Guo,2 Zhiqiang Ye1 1Department of Emergency, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China; 2Department of Infectious Disease and Clinical Laboratory, The Third Affiliated Hospital of Sun Yat-San University, Guangzhou 510630, China *These authors contributed equally to this work Objective: MicroRNA (miR)-431 plays an essential role in various human cancer types, particularly in the process of invasion. However, the function and mechanism of miR-431-5p in the invasion of hepatocellular carcinoma (HCC) remain undefined.Methods: The expression levels of miR-431-5p and its potential target protein UROC28 in hepatocellular carcinoma cells and tissues were detected, and the levels of EMT markers in vivo and in vitro were also detected.Results: MiR-431-5p was downregulated in HCC cell lines and tissues and associated with vascular invasion and tumor encapsulation. Furthermore, miR-431-5p was able to influence the epithelialto- mesenchymal transition (EMT) process in HCCLM3 and HUH7 cells. Mechanistically, it was discovered that miR-431-5p repressed invasion by targeting UROC28. Furthermore, miR-431-5p influenced the EMT markers in HCCLM3 and HUH7 cells by downregulating UROC28 expression. Similarly, in vivo assays confirmed that miR-431-5p upregulation in HCC cells remarkably inhibited tumor proliferation and influenced the EMT markers.Conclusion: The current study has demonstrated that the miR-431-5p/UROC28 axis acts possible influence on the EMT in HCC. Upregulation of miR-431-5p could be an original approach for inhibiting tumor invasion. Keywords: hepatocellular carcinoma, microRNA-431, UROC28, PBOV1, epithelial-to-mesenchymal transition |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6177384/pdf https://www.dovepress.com/getfile.php?fileID=44988 |
| Ending Page | 6503 |
| Page Count | 15 |
| Starting Page | 6489 |
| ISSN | 11786930 |
| DOI | 10.2147/ott.s173840 |
| Journal | OncoTargets and therapy |
| Volume Number | 11 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-10-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Oncotargets and Therapy Gastroenterology and Hepatology Hepatocellular Carcinoma Microrna-431 Uroc28 Pbov1 Epithelial-to-mesenchymal Transition |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
