NDLI: The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women.

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The effect of grapefruit intake on endogenous serum estrogen levels in postmenopausal women.

Content Provider	Scilit
Author	Monroe, Kristine R. Stanczyk, Frank Z. Besinque, Kathleen H. Pike, Malcolm C.
Copyright Year	2013
Description	Although grapefruit intake leads to elevated serum estrogen levels when hormones are taken orally, there are no published data on the effect on endogenous levels. We conducted a pilot dietary intervention study among healthy postmenopausal volunteers to test whole grapefruit, 2 juices, and 1 grapefruit soda. Fifty-nine participants were recruited through the Love/Avon Army of Women. The study consisted of a 3-wk run-in, 2 wk of grapefruit intake, and a 1-wk wash-out. Eight fasting blood samples were collected. An additional 5 samples drawn at 1, 2, 4, 8, and 10 hr after grapefruit intake were collected during an acute-phase study for 10 women. Serum assays for estrone $(E_{1}$), estradiol $(E_{2}$), estrone-3-sulfate $(E_{1}$S), dehydroepiandrosterone sulfate, and sex hormone-binding globulin were conducted. Whole grapefruit intake had significant effects on endogenous $E_{1}$S. Peak effects were seen at 8 hr, increasing by 26% from baseline. No changes in mean $E_{1}$ or $E_{2}$ with whole fruit intake were observed. In contrast, fresh juice, bottled juice, and soda intake all had significant lowering effects on $E_{2}$. The findings suggest an important interaction between grapefruit intake and endogenous estrogen levels. Because endogenous estrogen levels are associated with breast cancer risk, further research is warranted.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5796810/pdf
ISSN	01635581
e-ISSN	15327914
DOI	10.1080/01635581.2013.795982
Journal	Nutrition and Cancer
Issue Number	5
Volume Number	65
Language	English
Publisher	Informa UK Limited
Publisher Date	2013-07-16
Access Restriction	Open
Subject Keyword	Journal: Nutrition and Cancer Nutrition and Dietetics Physiology Breast Cancer Grapefruit Intake Cancer Risk Postmenopausal Serum Estrogen Levels Intake and Endogenous
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Cancer Research Oncology

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