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Further observations on coronavirus infection of primate CNS
| Content Provider | Scilit |
|---|---|
| Author | Murray, Ronald S. Cai, Guang-Yun Soike, Kenneth F. Cabirac, Gary F. |
| Copyright Year | 1997 |
| Description | Previously, we demonstrated that intracerebral (IC) inoculation of a murine coronavirus, MHV-JHM, into two species of primates can result in acute encephalomyelitis (Murray et al., 1992a). Infectious virus isolated from acutely infected animals, designated JHM-OMp1, was inoculated IC into a second group of monkeys. In this report we describe observations on the acutely infected animals and those surviving the acute infection were sacrificed at later times post-infection. Results from dual in situ hybridization/immunohistochemistry screening of tissues show that astrocytes are target cells in white matter lesions during acute infection. In animals sacrificed 150 days post-infection, areas of demyelinated gliotic lesions, prominent in the spinal cord, were seen throughout the neuraxis. No virus products were detected in these late-infection lesions. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/13550289709015795?needAccess=true |
| Ending Page | 75 |
| Page Count | 5 |
| Starting Page | 71 |
| ISSN | 13550284 |
| e-ISSN | 15382443 |
| DOI | 10.3109/13550289709015795 |
| Journal | Journal of NeuroVirology |
| Issue Number | 1 |
| Volume Number | 3 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1997-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Neurovirology Virology Infection Lesions Animals Coronavirus Primate Surviving Sacrificed Jhm |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neurology Virology Neurology (clinical) Cellular and Molecular Neuroscience |
