NDLI: Non-Orai Partners of STIM Proteins

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Non-Orai Partners of STIM Proteins

Content Provider	Scilit
Author	Groschner, Klaus Shrestha, Niroj Fameli, Nicola
Copyright Year	2017
Description	The discovery of stromal interaction molecules (STIM), STIM1 and STIM2, as signaling elements that govern $Ca^{2+}$ entry by reversibly bridging the intermembrane gap between the cortical endoplasmic reticulum (ER) and plasma membrane (PM) has resulted in a considerable gain in knowledge of the molecular mechanisms underlying ER–PM junctional communication. Progress in understanding the structural basis of the $Ca^{2+}$ entry pathway mediated by coupling of STIM1 to the PM $Ca^{2+}$ channel Orai is paralleled by rapidly accumulating information on STIM-associated signaling events and on alternative (non-Orai) or auxiliary interaction partners of STIM (see Chapters 3 and 10). The highly divergent target molecules of STIMs reside within as well as outside of junctional ER structures and include cation channel effectors as well as junctional regulators and scaffolds. The signaling function of STIM embraces not only ER luminal $Ca^{2+}$ sensing and the regulation of $Ca^{2+}$ handling proteins but also dynamic architectural ER remodeling. Here we aim to provide an outline of the emerging picture of STIM proteins as multifunctional and highly versatile ER-resident molecular switches involved in cellular $Ca^{2+}$ homeostasis and beyond. Book Name: Calcium Entry Channels in Non-Excitable Cells
Related Links	https://content.taylorfrancis.com/books/download?dac=C2015-0-66093-7&isbn=9781315152592&doi=10.1201/9781315152592-10&format=pdf
Ending Page	196
Page Count	20
Starting Page	177
DOI	10.1201/9781315152592-10
Language	English
Publisher	Informa UK Limited
Publisher Date	2017-07-14
Access Restriction	Open
Subject Keyword	Book Name: Calcium Entry Channels in Non-excitable Cells Structural Sup Function Stim Proteins Stim1 Reside
Content Type	Text
Resource Type	Chapter

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