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Plasma Alarin Level and Its Influencing Factors in Obese Newly Diagnosed Type 2 Diabetes Patients
| Content Provider | Scilit |
|---|---|
| Author | Zhou, Xin Luo, Mei Zhou, Sha Cheng, Zhiling Chen, Zhongpei Yu, Xiaoxia |
| Copyright Year | 2021 |
| Abstract | Objective: To investigate the plasma alarin level in newly diagnosed obese type 2 diabetes mellitus (T2DM) and its correlation with glucose and lipid metabolism and insulin resistance. Methods: From October 2018 to June 2020, 239 newly diagnosed T2DM patients were collected. According to obesity, patients were divided into T2DM obese group (n=135) and T2DM non-obese group (n =104). Gender, age, body mass index (BMI), blood lipids, blood glucose, glycosylated hemoglobin A1c (HbA1c), fasting insulin (FINS), plasma alarin concentration, homeostasis model assessment for insulin resistance (HOMA-IR), homeostasis model assessment for β-cell function (HOMA-β) and other clinical data were collected and analyzed. Results: BMI, triacylglycerol (TG), total cholesterol (TC), low-density lipoprotein-cholesterol (LDL-C), fasting blood glucose (FPG), HbA1c, FINS, plasma alarin levels and HOMA-IR in the control group, T2DM non-obese group and T2DM obese group increased sequentially, and high-density lipoprotein-cholesterol (HDL-L) and HOMA-β decreased sequentially (P< 0.05). Correlation analysis results showed that plasma alarin levels in T2DM patients were positively correlated with waistline, BMI, TC, LDL-C, FPG, HbA1c, FINS and HOMA-IR (P< 0.05), and negatively correlated with HDL-C and HOMA-β (P < 0.05), and the correlation coefficient of T2DM obese group was significantly higher than that of T2DM non-obese group (P< 0.05). Multiple linear stepwise regression analysis showed that BMI, FPG, HbA1c, HOMA-β, and HOMA-IR were independent factors related to plasma alarin levels in T2DM non-obese and T2DM obese patients, and the correlation coefficient of the T2DM obese group was significantly higher than that of the T2DM non-obese group (P < 0.05). Conclusion: Plasma alarin levels increase in newly diagnosed T2DM and obese T2DM patients, which are affected by TC, BMI, FPG, HbA1c, HOMA-β and HOMA-IR, and may be involved in development of T2DM. |
| Related Links | https://www.dovepress.com/getfile.php?fileID=66017 |
| Ending Page | 385 |
| Page Count | 7 |
| Starting Page | 379 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s290072 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | 14 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2021-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Endocrinology and Metabolism Type 2 Diabetes Mellitus Obesity Plasma Alarin Level Insulin Resistance Blood Sugar Blood Lipids Insulin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Pharmacology |
