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Features and Outcome of Advanced Neuroblastoma with Distant Lymph Node Metastasis
| Content Provider | Scilit |
|---|---|
| Author | Yamada, Shinichi Ishii, Eiichi Nakagawara, Akira Akazawa, Kouhei Tasaka, Hideko Kajiwara, Makoto Kawakami, Kiyoshi Ueda, Kohji |
| Copyright Year | 1992 |
| Description | We examined 52 children with advanced neuroblastoma who were diagnosed and treated during the past 7 years, and investigated the correlation between the degree of lymph node (LN) metastasis and the prognosis of neuroblastoma. In 8 of the 52 patients, distant LN metastasis was confumed both radio-graphically and histologically. The urinary homovanillic acid (HVA) level was markedly elevated in these patients, and it was higher than that in patients with regional LN metastasis (P <.05). The urinary vanillylmandelic acid (VMA) level and the VMA/HVA ratio were not significantly different between patients with regional and distant LN metastasis. None of the four examined patients with distant LN metastasis showed N-myc amplification of neuroblastoma tumors. An analysis of the survival rate in each patient group classified according to the degree of LN metastasis showed that the prognosis of the patients without LN mehtasis or with distant LN metastasis tended to be better than that of patients with regional LN metastasis. Our results indicate that patients with distant LN metastasis may belong to a subclass with different biological features and a better prognosis than those of other groups. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/08880019209006396 |
| Ending Page | 56 |
| Page Count | 8 |
| Starting Page | 49 |
| ISSN | 08880018 |
| e-ISSN | 15210669 |
| DOI | 10.3109/08880019209006396 |
| Journal | Pediatric hematology and oncology |
| Issue Number | 1 |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1992-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Pediatric Hematology and Oncology Pediatrics and Child Health Children Neuroblastoma Distant Ln Metastasis Node Lymph |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Pediatrics, Perinatology and Child Health Oncology |
