NDLI: Spiral Ganglion Changes After Massive Aminoglycoside Treatment in the Guinea Pig

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Spiral Ganglion Changes After Massive Aminoglycoside Treatment in the Guinea Pig

Content Provider	Scilit
Author	Koitchev, Konstantin Guilhaume, Anne Cazals, Yves Aran, Jean-Marie
Copyright Year	1982
Description	Morphological changes of the eighth nerve were observed in the guinea pig between 1 month and 1 year after treatment with large doses of the antibiotic amikacin which resulted in complete cochlear hair cell destruction. The neural retrograde degeneration was found to be relatively fast, with a considerable loss (30 to 55%) of ganglion cells one month after treatment, continuously increasing (up to 85%) after one year. Gross changes in the habenula perforata and in the spiral ganglion are described, together with ultrastructural alterations of organelles important for the cell metabolism and axonal transport. The rapid degeneration and the morphological findings suggest a direct influence of toxic substances on the ganglion cells.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/00016488209128931
Ending Page	438
Page Count	8
Starting Page	431
ISSN	00016489
e-ISSN	16512251
DOI	10.3109/00016488209128931
Journal	Acta Oto-Laryngologica
Issue Number	1-6
Volume Number	94
Language	English
Publisher	Informa UK Limited
Publisher Date	1982-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oto-laryngologica Otorhinolaryngology Treatment Spiral Ganglion Neural Guinea Pig Ganglion Cells Morphological
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology

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