NDLI: Restless legs syndrome

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Restless legs syndrome

Content Provider	Scilit
Author	Ovallath, Sujith
Copyright Year	2012
Description	Background: Restless legs syndrome (RLS) is a common sleep-related disorder characterized by abnormal sensation and an urge to move the lower limbs. Symptoms occur at rest in the evening or at night, and they are alleviated by moving the affected extremity or by walking. Although the exact etiopathogenesis of RLS remains elusive, the rapid improvement of symptoms with dopaminergic agents suggests that dopaminergic system dysfunction may be a basic mechanism. Dopaminergic agents are the best-studied agents, and are considered first-line treatment of RLS. Objective: To review the diagnostic criteria, clinical features, etiopathogenesis, and the treatment options of RLS. Methods: The suggestions are based on evidence from studies published in peer-reviewed journals, or upon a comprehensive review of the medical literature. Results/conclusion: Extensive data are available for proving the link between the dopaminergic system and RLS. A possible genetic link also has been studied extensively. Dopamine agonists, especially pramipexole and ropinirole, are particularly useful in the treatment of RLS. Pharmacological treatment should however be limited to those patients who suffer from clinically relevant RLS with impaired sleep quality or quality of life.
Related Links	https://www.dovepress.com/getfile.php?fileID=14250
Ending Page	57
Page Count	9
Starting Page	49
e-ISSN	19277733
DOI	10.2147/jprls.s37451
Journal	Journal of Parkinsonism and Restless Legs Syndrome
Volume Number	2
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-10-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Parkinsonism and Restless Legs Syndrome Treatment Quality of Life Rls Legs Restless Move Dopaminergic Extremity Etiopathogenesis Sleep
Content Type	Text
Resource Type	Article

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