NDLI: Localisation of Secretory Leucocyte Proteinase Inhibitor mRNA in Nasal Mucosa

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Localisation of Secretory Leucocyte Proteinase Inhibitor mRNA in Nasal Mucosa

Content Provider	Scilit
Author	Westin, Ulla Fryksmark, Ulla Polling, Åsa Ohlsson, Kjell
Copyright Year	1994
Description	Human secretory leucocyte proteinase inhibitor (SLPI) is a low-molecular weight, acid-stable inhibitor of polymorph-nuclear granulocyte elastase and cathepsin G. Previous reports have demonstrated the existence of SLPI in the respiratory tract, salivary glands and cervical mucosa. Positive staining for SLPI using immunohistochemical techniques has been reported in serous glands in nasal mucosa. We now confirm this observation and show, using in situ hybridization, that the pattern of expression of mRNA corresponds to the distribution of the encoded protein, SLPI. This, together with the high concentration of SLPI in nasal secretions, confirms the hypothesis of a local production of SLPI in the mucous membranes.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/00016489409126042
Ending Page	202
Page Count	4
Starting Page	199
ISSN	00016489
e-ISSN	16512251
DOI	10.3109/00016489409126042
Journal	Acta Oto-Laryngologica
Issue Number	2
Volume Number	114
Language	English
Publisher	Informa UK Limited
Publisher Date	1994-01-01
Access Restriction	Open
Subject Keyword	Journal: Acta Oto-laryngologica Nasal Mucosa Mrna
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology

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