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Long time-lapse imaging reveals unique features of PARK2/Parkin-mediated mitophagy in mature cortical neurons
| Content Provider | Scilit |
|---|---|
| Author | Cai, Qian Zakaria, Hesham Mostafa Sheng, Zu-Hang |
| Copyright Year | 2012 |
| Description | Proper degradation of aged and damaged mitochondria through mitophagy is essential to ensure mitochondrial integrity and function. Translocation of PARK2/Parkin onto damaged mitochondria induces mitophagy in many non-neuronal cell types. However, direct evidence showing PARK2-mediated mitophagy in mature neurons is controversial, leaving unanswered questions as to how, where, and by what time course PARK2-mediated mitophagy occurs in neurons following mitochondrial depolarization. We applied long time-lapse imaging in live mature cortical neurons to monitor the slow but dynamic and spatial PARK2 translocation onto damaged mitochondria and subsequent degradation through the autophagy-lysosomal pathway. In comparison with non-neuronal cells, our study reveals unique features of PARK2-mediated mitophagy in mature neurons, which will advance our understanding of pathogenesis of several major neurodegenerative diseases characterized by damaged mitochondria or a dysfunctional autophagy-lysosomal system. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/auto.20218?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3427264/pdf |
| Ending Page | 978 |
| Page Count | 3 |
| Starting Page | 976 |
| ISSN | 15548627 |
| e-ISSN | 15548635 |
| DOI | 10.4161/auto.20218 |
| Journal | Autophagy |
| Issue Number | 6 |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2012-06-23 |
| Access Restriction | Open |
| Subject Keyword | Journal: Autophagy Cell Biology Mitochondria Parkin Park2 Lysosome Autophagosome Autophagy Depolarization Mitochondrial Mobility Neuronal Mitophagy Mitochondrial Membrane Potential Mitochondrial Quality Control |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Molecular Biology |
