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Protective effect of morin on cardiac mitochondrial function during isoproterenol-induced myocardial infarction in male Wistar rats
| Content Provider | Scilit |
|---|---|
| Author | Numair, Khalid S. Al Chandramohan, Govindasamy Alsaif, Mohammed A. Baskar, Arul Albert |
| Copyright Year | 2012 |
| Description | Altered mitochondrial function and free radical-mediated tissue damage have been suggested as an important pathological event in isoproterenol (ISO)-induced cardiotoxicity. This study was undertaken to know the preventive effect of morin on mitochondrial damage in ISO-induced cardiotoxicity in male Wistar rats. Myocardial infarction (MI) in rats was induced by ISO (85 mg/kg) at an interval of 24 hours for 2 days. Morin was given to rats as pre-treatment for 30 days orally using an intragastric tube. ISO-treated rats showed a significant elevation of mitochondrial thiobarbituric acid reactive substances (TBARS) and hydrogen peroxide (HP) level and pre-treatment with morin significantly prevented the increase of TBARS and HP level to near normality. The level of enzymic and non-enzymic antioxidants was decreased significantly in ISO-treated rats and pre-treatment with morin significantly increased the levels of superoxide dismutase, catalase, glutathione peroxidase, glutathione-S-transferase, glutathione reductase, and reduced glutathione to normality. The activities of mitochondrial enzymes such as isocitrate dehydrogenase, alpha-ketoglutarate dehydrogenase, succinate dehydrogenase, and malate dehydrogenase were decreased significantly in ISO-treated myocardial ischemic rats and upon pre-treatment with morin restored these enzymes activity to normality. In addition, the decreased activities of cytochrome-C oxidase and NADH-dehydrogenases were observed in ISO-treated rats and pre-treatment with morin prevented the activities of cytochrome-C oxidase and NADH-dehydrogenase to normality. Pre-treatment with morin favorably restored the biochemical and functional parameters to near normal indicating morin to be a significant protective effect on cardiac mitochondrial function against ISO-induced MI in rats. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1179/1351000211Y.0000000019?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6837627/pdf |
| Ending Page | 21 |
| Page Count | 8 |
| Starting Page | 14 |
| ISSN | 13510002 |
| e-ISSN | 17432928 |
| DOI | 10.1179/1351000211y.0000000019 |
| Journal | Redox Report |
| Issue Number | 1 |
| Volume Number | 17 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2012-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Redox Report Andrology Toxicology Morin Isoproterenol Myocardial Infarction Mitochondrial Enzymes Lipid Peroxidation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Biochemistry (medical) Cell Biology Physiology Biochemistry Clinical Biochemistry |
