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Evaluation of Urinary Neutrophil Gelatinase Associated Lipocalin and Kidney Injury Molecule-1 as Diagnostic Markers for Early Nephropathy in Patients with Type 2 Diabetes Mellitus
| Content Provider | Scilit |
|---|---|
| Author | Huynh, Quang Thuan Pham, Nguyet Minh Pham, Diep Thao Hoang, Minh Thi Dam, Lan Phuong Thi Ho, Hang Thi Phan, Van Anh Can, Luong Thang Ngo, Thi Tuyet Mai Dang, Duy Quy Do, Nhu Binh Nghiem, Duc Thuan |
| Copyright Year | 2020 |
| Description | Purpose: The purpose of this study was evaluating the early diagnostic value of two specific tubular markers neutrophil gelatinase-associated lipocalin (NGAL) and kidney injury molecule-1 (KIM-1) in diabetes nephropathy. Patients and Methods: Cross-sectional study was carried in three groups of patients from 10/2017 to 10/2018 in Military Hospital 103. Group I included 30 healthy peoples with estimated glomerular filtration rate (eGFR) > 60 mL/min/1.73 $m^{2}$ and urine albumin creatinine ratio (uACR) < 30 mg/g. Group II included 30 type 2 diabetic patients having uACR < 30 mg/g, eGFR > 60 mL/min/1.73 $m^{2}$. Group III included 30 type 2 diabetic patients having uACR > 30 mg/g, eGFR > 60 mL/min/1.73 $m^{2}$. Results: Urine KIM-1 and NGAL increased progressively from control group (57.29 ± 25.91 pg/mL; 25.71 ± 13.69 ng/mL) to the group of diabetic patients with uACR < 30 mg/g (167.06 ± 44.01 pg/mL; 37.42 ± 10.89 ng/mL) and the group of diabetic patients with uACR ≥ 30 mg/g) (p < 0.05). There were moderate correlations between KIM-1 (r = 0.48, p < 0.05) and NGAL (r = 0.45, p < 0.05) with uACR. There was a mild correlation between KIM-1 and NGAL (r = 0.29, p < 0.05). KIM-1 and NGAL are the independent tests to detect diabetic nephropathy. The sensivity and specificity of KIM-1 with cut-off value of 174.95 pg/mL were 62.37% and 73.48%, respectively; the sensivity and specificity of NGAL with cut-off value of 35.2 ng/mL were 60.45% and 70.37%, respectively. Conclusion: KIM-1 and NGAL in urine are independent markers for early diagnostic diabetic nephropathy. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7322140/pdf https://www.dovepress.com/getfile.php?fileID=59136 |
| Ending Page | 2207 |
| Page Count | 9 |
| Starting Page | 2199 |
| ISSN | 11787007 |
| DOI | 10.2147/dmso.s258678 |
| Journal | Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
| Volume Number | 13 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-06-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Oncology Albumin Urine Diabetic Kidney Disease Urine Albumin Creatinin Ratio |
| Content Type | Text |
| Resource Type | Article |
| Subject | Internal Medicine Pharmacology |
