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Ovarian metastasis from lung adenocarcinoma with ALK-positive rearrangement detected by next generation sequencing: A case report and literatures review
| Content Provider | Scilit |
|---|---|
| Author | Jing, Xuquan Li, Feng Meng, Xue Liu, Zhitong Yu, Jinming Liu, Bo |
| Copyright Year | 2017 |
| Description | Ovarian metastasis is an exceptionally rare condition in lung adenocarcinoma patients and is often difficult to distinguish from primary ovarian carcinoma. ALK (anaplastic lymphoma kinase) tyrosine kinase inhibitors elicit a significant objective response rate and are well-tolerated in advanced ALK-positive lung cancer. Hence, we report a case of a 41-year-old woman with ovarian metastases from NSCLC. After receiving a 6 course first line chemotherapy and 8 course maintenance therapy, the patient suffered acute abdominal pain, so surgery was performed. ALK rearrangement was detected by next generation sequencing, with a 13% abundance of ALK fusion. Crizotinib was administered, and the disease remained stable after 10 months of crizotinib therapy. Further, we reviewed the literature related to characteristics of metastatic ovarian malignancies that form from lung tumors, the utility of ALK inhibition for treating ALK-positive NSCLC, the molecular diagnosis of ALK rearrangement and the role of next generation sequencing for ALK rearrangement detection. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/15384047.2017.1310344?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5499758/pdf |
| Ending Page | 284 |
| Page Count | 6 |
| Starting Page | 279 |
| ISSN | 15384047 |
| e-ISSN | 15558576 |
| DOI | 10.1080/15384047.2017.1310344 |
| Journal | Cancer Biology & Therapy |
| Issue Number | 5 |
| Volume Number | 18 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-03-31 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cancer Biology & Therapy Medical Laboratory Technology Alk Lung Adenocarcinoma Next Generation Sequencing Ovarian Metastasis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Pharmacology Molecular Medicine Oncology |
