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MicroRNAs and cancer: An overview
| Content Provider | Scilit |
|---|---|
| Author | Medina, Pedro P. Slack, Frank |
| Copyright Year | 2008 |
| Description | MicroRNAs (miRNAs) are a recently discovered class of small RNA molecules that negatively regulate gene expression at the post-transcriptional level. MiRNAs play key roles in development and establishment of cell identity and aberrant metabolism/expression of miRNAs has been linked to human diseases including cancer. Components of the miRNA machinery and miRNAs themselves are involved in many cellular processes that are altered in cancer, such as differentiation, proliferation and apoptosis. Some miRNAs exhibit differential expression levels in cancer and have demonstrated capability to affect cellular transformation, carcinogenesis and metastasis acting either as oncogenes or tumour suppressors. We are only beginning to comprehend the functional repercussions of the gain or loss of particular microRNAs on cancer. Nonetheless, although microRNAs have been discovered in humans a mere eight years ago, a host of promising potential applications in the diagnosis, prognoses and therapy of cancer are emerging at a rapid pace. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.4161/cc.7.16.6453?needAccess=true |
| Ending Page | 2492 |
| Page Count | 8 |
| Starting Page | 2485 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.7.16.6453 |
| Journal | Cell Cycle |
| Issue Number | 16 |
| Volume Number | 7 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2008-08-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Medical Laboratory Technology Differentiation Metastasis Apoptosis Gene Expression Functional Mirnas Discovered Micrornas and Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
