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Nine-year change in statistical design, profile, and success rates of Phase II oncology trials
| Content Provider | Scilit |
|---|---|
| Author | Ivanova, Anastasia Paul, Barry Marchenko, Olga Song, Guochen Patel, Neerali Moschos, Stergios J. |
| Copyright Year | 2015 |
| Description | We investigated nine-year trends in statistical design and other features of Phase II oncology clinical trials published in 2005, 2010, and 2014 in five leading oncology journals: Cancer, Clinical Cancer Research, Journal of Clinical Oncology, Annals of Oncology, and Lancet Oncology. The features analyzed included cancer type, multicenter vs. single-institution, statistical design, primary endpoint, number of treatment arms, number of patients per treatment arm, whether or not statistical methods were well described, whether the drug was found effective based on rigorous statistical testing of the null hypothesis, and whether the drug was recommended for future studies. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5995106/pdf |
| Ending Page | 149 |
| Page Count | 9 |
| Starting Page | 141 |
| ISSN | 10543406 |
| e-ISSN | 15205711 |
| DOI | 10.1080/10543406.2015.1092030 |
| Journal | Journal of Biopharmaceutical Statistics |
| Issue Number | 1 |
| Volume Number | 26 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-09-14 |
| Access Restriction | Open |
| Subject Keyword | Journal: Journal of Biopharmaceutical Statistics Public Health and Health Services Fleming's Design Oncology Phase Ii Trials Simon's Design Two-stage Design |
| Content Type | Text |
| Resource Type | Article |
| Subject | Statistics and Probability Pharmacology Pharmacology (medical) |
