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The evolving relationship between adiponectin and insulin sensitivity in hepatitis C patients during viral clearance
| Content Provider | Scilit |
|---|---|
| Author | Chang, Ming-Ling Kuo, Chia-Jung Pao, Li-Heng Hsu, Chen-Ming Chiu, Cheng-Tang |
| Copyright Year | 2017 |
| Description | Background: The evolution of the relationship between adiponectin and insulin sensitivity in hepatitis C virus (HCV) patients during viral clearance is unclear and warrants investigation. Methods: A prospective study including 747 consecutive chronic hepatitis C (CHC) patients, of whom 546 had completed a course of anti-HCV therapy and underwent pre-, peri- and post-therapy surveys for anthropomorphic, viral, metabolic and hepatic profiles and adiponectin levels, was conducted in a tertiary care center. Results: Multivariate analyses indicated associations of sex, triglyceride levels and hepatic steatosis with adiponectin levels and of triglyceride levels and interferon λ3 (IFNL3) genotype with homeostasis model assessment-estimated insulin resistance (HOMA-IR) levels before anti-HCV therapy. In patients with a sustained virological response (SVR; n = 455), at 24 weeks post-therapy, sex, BMI, aspartate aminotransferase to platelet ratio index (APRI), HOMA-IR and steatosis were associated with adiponectin levels, and IFNL3 genotype was associated with HOMA-IR levels. GEE analysis demonstrated that SVR affected longitudinal trends in adiponectin levels. Compared with pre-therapy levels, adiponectin and APRI levels decreased 24 weeks post-therapy in SVR patients, regardless of baseline insulin resistance (IR). However, HOMA-IR levels decreased in SVR patients with baseline IR but increased in those without baseline IR. Compared with controls, immunohistochemical studies showed that pre-therapy CHC patients had higher hepatic adiponectin expression associated with hepatic fibrosis. Conclusions: During HCV infection, adiponectin may affect insulin sensitivity through triglycerides. After viral clearance, adiponectin levels were directly associated with insulin sensitivity and decreased upon improved hepatic fibrosis; with a link to the IFNL3 genotype, insulin sensitivity improved only in patients with baseline IR. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/21505594.2017.1300734?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5711434/pdf |
| Ending Page | 1264 |
| Page Count | 10 |
| Starting Page | 1255 |
| ISSN | 21505594 |
| e-ISSN | 21505608 |
| DOI | 10.1080/21505594.2017.1300734 |
| Journal | Virulence |
| Issue Number | 7 |
| Volume Number | 8 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2017-10-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: Virulence Medical Laboratory Technology Virology Adiponectin Hcv Homa-ir Insulin Sensitivity Triglycerides |
| Content Type | Text |
| Resource Type | Article |
| Subject | Infectious Diseases Parasitology Immunology Microbiology Microbiology (medical) |
