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Serum visinin-like protein-1 in concussed professional ice hockey players
| Content Provider | Scilit |
|---|---|
| Author | Shahim, Pashtun Mattsson-Carlgren, Niklas Macy, Elizabeth M. Crimmins, Dan L. Ladenson, Jack H. Zetterberg, Henrik Blennow, Kaj Tegner, Yelverton |
| Copyright Year | 2015 |
| Description | Primary objective: Visinin-like protein-1 (VILIP-1) has shown potential utility as a biomarker for neuronal injury in cerebrospinal fluid. This study investigated serum VILIP-1 as a diagnostic and prognostic marker in sports-related concussion. Methods: This multi-centre prospective cohort study involved the 12 teams of the professional ice hockey league in Sweden. A total of 288 players consented to participate in the study. Thirty-five players sustained concussions, of whom 28 underwent repeated blood samplings at 1, 12, 36 and 144 hours after the trauma or when the player returned to play (7–90+ days). Main outcomes and results: The highest levels of VILIP-1 were measured 1 hour after concussion and the levels decreased during rehabilitation, reaching a minimum level at the 36-hour sampling. However, the levels of serum VILIP-1 at 1 hour after concussion were not significantly higher than pre-season baseline values. Serum levels of VILIP-1 1 hour post-concussion did not correlate with the number of days for the concussion symptoms to resolve. Further, serum levels of VILIP-1 increased after a friendly game in players who were not concussed. Conclusions: These results provide evidence that serum VILIP-1 may not be a useful biomarker for diagnosis and prognosis of sports-related concussion. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.3109/02699052.2015.1018324 |
| Ending Page | 876 |
| Page Count | 5 |
| Starting Page | 872 |
| ISSN | 02699052 |
| e-ISSN | 1362301X |
| DOI | 10.3109/02699052.2015.1018324 |
| Journal | Brain Injury |
| Issue Number | 7-8 |
| Volume Number | 29 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2015-05-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Brain Injury Sport Sciences Biomarker Brain Injury Concussion Ice Hockey Vilip-1 |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Developmental and Educational Psychology Neurology (clinical) |
