NDLI: Long-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review

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Long-term progression-free survival of apatinib monotherapy for relapsed ovarian cancer: a case report and literature review

Content Provider	Scilit
Author	Zhang, Di Huang, Jiaqi Sun, Yulan Guo, Qisen
Copyright Year	2019
Description	Abstract: Ovarian cancer is the deadliest gynecologic malignancy, which poses a great threat to female health. Anti-angiogenic therapy could bring clinical benefit for patients with ovarian cancer. Apatinib, an oral small-molecule vascular endothelial growth factor receptor-2 inhibitor, has shown notable therapeutic effect in a wide variety of tumors. We report a woman with advanced ovarian cancer who received apatinib at 250 mg/day after failure of multiple-line treatment regimens, followed by discussion through review of literature. The patient has quite a long progression-free survival time of 24 months, with a satisfactory quality of life. Apatinib monotherapy may provide an additional option for advanced ovarian cancer，but it still needs further observation and exploration.
Related Links	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6529614/pdf https://www.dovepress.com/getfile.php?fileID=49878
Ending Page	3644
Page Count	10
Starting Page	3635
ISSN	11786930
DOI	10.2147/ott.s198946
Journal	OncoTargets and therapy
Volume Number	12
Language	English
Publisher	Informa UK Limited
Publisher Date	2019-05-01
Access Restriction	Open
Subject Keyword	Journal: Oncotargets and Therapy Obstetrics and Gynecology Anti-angiogenic Therapy Apatinib Monotherapy Ovarian Cancer Vascular Endothelial Growth Factor Receptor
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Oncology

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