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Roles of the ubiquitin-proteosome system in neurogenesis
| Content Provider | Scilit |
|---|---|
| Author | Tuoc, Tran Cong Stoykova, Anastassia |
| Copyright Year | 2010 |
| Description | The ubiquitin-proteosome system (UPS) is a non-lysosomal proteolysis system involved in the degradation of irrelevant/misfolded intracellular proteins. The protein substrates of this system are tagged by ubiquitin in sequential reactions that target them for proteasome-dependent destruction. In the developing central nervous system, ubiquitin-mediated proteolysis has recently emerged as an important player in the regulation of neural progenitor proliferation, cell specification, neuronal differentiation, maturation, and migration. E3 ubiquitin ligases are crucial components in the UPS because they provide the specificity that determines which substrates are targeted for ubiquitin-dependent proteolysis. In this review, we discuss the molecular mechanisms of the UPS, focusing primarily on the roles of E3 ligases and their substrates in sequential steps of neurogenesis. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.4161/cc.9.16.12551?needAccess=true https://www.landesbioscience.com/journals/cc/TuocCC9-16.pdf |
| Ending Page | 3200 |
| Page Count | 7 |
| Starting Page | 3194 |
| ISSN | 15384101 |
| e-ISSN | 15514005 |
| DOI | 10.4161/cc.9.16.12551 |
| Journal | Cell Cycle |
| Issue Number | 16 |
| Volume Number | 9 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-08-15 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Cycle Developmental Biology Central Nervous System Proteolysis Neuronal Differentiation Proliferation Molecular Mechanisms Ubiquitin Proteosome Proteosome System Neurogenesis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Developmental Biology Medicine Molecular Biology |
