NDLI: Immunotherapy of hepatocellular carcinoma

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Immunotherapy of hepatocellular carcinoma

Content Provider	Scilit
Author	Pardee, Angela D. Butterfield, Lisa H.
Copyright Year	2012
Description	Current therapies for advanced hepatocellular carcinoma (HCC) are marginally effective and exacerbate underlying liver disease. The ability of immunotherapy to elicit nontoxic, systemic, long-lived anti-tumor activity makes it particularly well-suited for use in the setting of HCC. While therapeutic benefit has been achieved in early clinical trials, the efficacy of immune-based therapies is limited by several unique properties of HCC, most notably the inherently tolerogenic character of the liver in both healthy and diseased (chronically-infected or tumor-bearing) states. Therapeutic regimens that both counteract these immunosuppressive mechanisms and amplify tumor-specific immunity are expected to profoundly improve clinical outcomes for HCC patients.
Related Links	https://www.tandfonline.com/doi/pdf/10.4161/onci.1.1.18344?needAccess=true https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3376967/pdf
Ending Page	55
Page Count	8
Starting Page	48
e-ISSN	2162402X
DOI	10.4161/onci.1.1.18344
Journal	OncoImmunology
Issue Number	1
Volume Number	1
Language	English
Publisher	Informa UK Limited
Publisher Date	2012-01-01
Access Restriction	Open
Subject Keyword	Journal: Oncoimmunology Gastroenterology and Hepatology Alpha-fetoprotein Cancer Vaccine Cirrhosis Combination Therapies Hepatitis Hepatocellular Carcinoma
Content Type	Text
Resource Type	Article

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