NDLI: Modeling the Effects of Hydroxypropylcellulose in Acetaminophen Tablet Formulation

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Modeling the Effects of Hydroxypropylcellulose in Acetaminophen Tablet Formulation

Content Provider	Scilit
Author	Harcum, W. W. Skinner, G. W. Altekar, M. Joneja, S. K. Barnum, P. E. Guo, Jian-Hwa
Copyright Year	1998
Description	The objective of the research described here was to develop a set of predictive models that would be used to show the performance of hydroxypropylcellulose as a pharmaceutical tablet binder. A statistically designed set of experiments was used to relate tablet formulation to functionality. It was found that the binder level affected both hardness and dissolution time. Useful predictive models were generated for tablet hardness and dissolution time as a function of the binder or binder-drug ratio. The optimal formulation can be predicted from this study, and will depend upon the combination of desired hardness and the dissolution time for a particular drug.
Related Links	http://www.tandfonline.com/doi/pdf/10.3109/03639049809097270
Ending Page	918
Page Count	8
Starting Page	911
ISSN	03639045
e-ISSN	15205762
DOI	10.3109/03639049809097270
Journal	Drug Development and Industrial Pharmacy
Issue Number	10
Volume Number	24
Language	English
Publisher	Informa UK Limited
Publisher Date	1998-01-01
Access Restriction	Open
Subject Keyword	Journal: Drug Development and Industrial Pharmacy Pharmacology and Pharmacy Predictive Models Hydroxypropylcellulose Tablet Formulation Hardness and Dissolution Drug Acetaminophen Tablet Dissolution Time
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Drug Discovery Pharmacology Pharmaceutical Science

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