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Plasma lipocalin-2 levels in pregnant women with pre-eclampsia, and their relation with severity of disease
| Content Provider | Scilit |
|---|---|
| Author | Arikan, Deniz Cemgil Özkaya, Mesut Adali, Ertan Kilinc, Metin Coskun, Ayhan Ozer, Ali Bilge, Fidan |
| Copyright Year | 2010 |
| Description | To compare lipocalin-2 (LCN2) levels in pre-eclamptic women with those in healthy pregnant women, and to determine whether there is a correlation between LCN2 levels and the severity of the disease. The study included 66 pregnant women: 22 healthy pregnant women (Group 1), 23 women with mild pre-eclampsia (Group 2), and 21 women with severe pre-eclampsia (Group 3). Pre-eclamptic women and normal controls were carefully matched for maternal age, gestational age, and body mass index (BMI). The maternal levels of plasma LCN2 were determined by enzyme-linked immunosorbent assay. Plasma LCN2 levels in the pre-eclamptic group were significantly lower than those in the healthy control group (p < 0.05). Although plasma LCN2 level was lower in the severe compared to the mild pre-eclamptic group, the difference was not statistically significant (p > 0.05). There was no significant correlation between LCN2 levels and the homeostasis model assessment of insulin resistance (HOMA-IR), BMI, triglyceride, gestational week at delivery, birth weight, and systolic and diastolic blood pressure in pre-eclamptic and healthy pregnant women (p > 0.05). Our results show that there are decreased concentrations of plasma LCN2 in pre-eclamptic subjects and this may indicate that LCN2 plays a role in the pathogenesis of pre-eclampsia. However, further experiments are needed to clarify this role. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/14767058.2010.487138 |
| Ending Page | 296 |
| Page Count | 6 |
| Starting Page | 291 |
| ISSN | 14767058 |
| e-ISSN | 14764954 |
| DOI | 10.3109/14767058.2010.487138 |
| Journal | The Journal of Maternal-Fetal & Neonatal Medicine |
| Issue Number | 2 |
| Volume Number | 24 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-05-27 |
| Access Restriction | Open |
| Subject Keyword | Journal: The Journal of Maternal-fetal & Neonatal Medicine Medical Laboratory Technology Severity of the Disease Pre Eclampsia Plasma Lipocalin Lcn2 Eclamptic Women Healthy Pregnant |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pediatrics, Perinatology and Child Health Obstetrics and Gynecology |
