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Long-term outcome of childhood acute myeloid leukemia in a developing country: experience from a children's hospital in China
| Content Provider | Scilit |
|---|---|
| Author | Xu, Xiao-Jun Tang, Yong-Min Song, Hua Yang, Shi-Long Shi, Shu-Wen Wei, Jian |
| Copyright Year | 2010 |
| Description | Data on childhood acute myeloid leukemia (AML) in developing countries are limited. Herein we report the outcome of childhood AML treated with modified NPCLC-AML97 in our institution from 1997 to 2005. One hundred and eighty-five children with newly diagnosed AML were admitted. The 7-year overall survival (OS) and event free survival (EFS) rates for the whole cohort were 33.1 ± 4.1% and 31.2 ± 3.7%, respectively. Sixty patients (32.4%) refused chemotherapy and 123 were eligible for protocol evaluation. Among eligible patients, 111 (90.2%) achieved complete remission (CR). The estimated 7-year OS and EFS rates were 50.2 ± 5.5% and 46.9 ± 5.1%, respectively. APL was more curable than non-APL (7-year EFS: 63.5 ± 7.9% vs. 35.9 ± 6.3%, p = 0.005). Thirty-one patients (25.2%) relapsed, but no central nervous system leukemia was observed. Although the cure rate of childhood AML in China was low, the treatment outcome for patients who could adhere to the treatment protocol was satisfactory. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10428194.2010.518653 |
| Ending Page | 2269 |
| Page Count | 8 |
| Starting Page | 2262 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428194.2010.518653 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 12 |
| Volume Number | 51 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2010-10-07 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Hematology Treatment Survival Leukemia Myeloid Apl Children's Eligible Childhood Aml |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
