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Urinary and Biliary Metabolites of Mephentermine in Male Wistar Rats
| Content Provider | Scilit |
|---|---|
| Author | Mori, Masa-Aki Uy, Narcisa Sakai, Yu Kikuko Inoue, Masami Miyahara, Tatsuro Kozuka, Hiroshi |
| Copyright Year | 1989 |
| Description | 1. Excretion of urinary and biliary radioactivity, and metabolites of [3H]mephentermine (MP), after i.p. or subcutaneous administration of [3H]MP to male Wistar rats, were determined by preparative t.l.c.-liquid scintillation counting. 2. About 45% of the radioactivity administered i.p. was excreted in the 24 h urine. The major urinary metabolite was conjugated p-hydroxymephentermine (p-hydroxy-MP), which accounted for about 18% of the administered radioactivity in the 24 h urine. 3. About 4·2% of the radioactivity administered subcutaneously was excreted in bile during 24 h. The major biliary metabolite was conjugated p-hydroxy-MP, which accounted for about 39% of the radioactivity excreted in the bile in 24 h. 4. Urinary and biliary minor metabolites detected were phentermine (Ph), p-hydroxyphentermine (p-hydroxy-Ph), N-hydroxyphentermine (N-hydroxy-Ph), N-hydroxymephentermine (N-hydroxy-MP) and their conjugates, and conjugated MP. 5. The conjugates were considered to be glucuronides from the inhibitory effect of saccharic acid 1,4-lactone on their hydrolysis with β-glucuronidase. 6. Biliary excretion rates of conjugated p-hydroxy-Ph and p-hydroxy-MP reached maxima at 3 to 4h, and non-conjugated metabolites were maximal at 1 to 2h, after administration. 50% of the biliary metabolites was excreted within 5 h. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/00498258909042274 |
| Ending Page | 299 |
| Page Count | 13 |
| Starting Page | 287 |
| ISSN | 00498254 |
| e-ISSN | 13665928 |
| DOI | 10.3109/00498258909042274 |
| Journal | Xenobiotica |
| Issue Number | 3 |
| Volume Number | 19 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1989-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Xenobiotica Endocrinology and Metabolism Wistar Rats Mephentermine Biliary Metabolites Urinary and Biliary Male Wistar |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Medicine Biochemistry Toxicology Pharmacology |
