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Ring finger protein 146/Iduna is a Poly(ADP-ribose) polymer binding and PARsylation dependent E3 ubiquitin ligase
| Content Provider | Scilit |
|---|---|
| Author | Zhou, Zhi-Dong Chan, Christine Hui-Shan Xiao, Zhi-Cheng Tan, Eng-King |
| Copyright Year | 2011 |
| Description | Recent findings suggest that Ring finger protein 146 (RNF146), also called iduna, have neuroprotective property due to its inhibition of Parthanatos via binding with Poly(ADP-ribose) (PAR). The Parthanatos is a PAR dependent cell death that has been implicated in many human diseases. RNF146/Iduna acts as a PARsylation-directed E3 ubquitin ligase to mediate tankyrase-dependent degradation of axin, thereby positively regulates Wnt signaling. RNF146/Iduna can also facilitate DNA repair and protect against cell death induced by DNA damaging agents or γ-irradiation. It can translocate to the nucleus after cellular injury and promote the ubiquitination and degradation of various nuclear proteins involved in DNA damage repair. The PARsylation-directed ubquitination mediated by RNF146/Iduna is analogous to the phosphorylation-directed ubquitination catalyzed by Skp1-Cul1-F-box (SCF) E3 ubiquitin complex. RNF146/Iduna has been found to be implicated in neurodegenerative disease and cancer development. Therefore modulation of the PAR-binding and PARsylation dependent E3 ligase activity of RNF146/Iduna could have therapeutic significance for diseases, in which PAR and PAR-binding proteins play key pathophysiologic roles. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3277779/pdf https://www.landesbioscience.com/journals/celladhesion/ZhouCAM5-6.pdf |
| Ending Page | 471 |
| Page Count | 9 |
| Starting Page | 463 |
| ISSN | 19336918 |
| e-ISSN | 19336926 |
| DOI | 10.4161/cam.5.6.18356 |
| Journal | Cell adhesion & migration |
| Issue Number | 6 |
| Volume Number | 5 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2011-11-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Cell Adhesion & Migration Biochemistry and Molecular Biology E3 Ubquitin Ligase Ring Finger Protein 146 Par-binding Proteins Parsylation Parthanatos Inhibitors Ubiquitination |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Cellular and Molecular Neuroscience |
