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Expression and Effects of Long Non-Coding RNA, LINC01124, in Non-Small Cell Lung Cancer
| Content Provider | Scilit |
|---|---|
| Author | Wang, Zi-Bo Zhang, Hong-Yan Lu, Ji-Bin |
| Copyright Year | 2020 |
| Description | Objective: To investigate the expression and evaluate the clinical significance of long non-coding RNA, LINC01124, in non-small cell lung cancer (NSCLC) and to study its influence in this tumor. Methods: Hundred specimens of NSCLC tissues and normal lung tissues after surgery were collected. The qRT-PCR for LINC01124 expression was performed on cancerous and normal lung tissues. The correlations between the expression of LINC01124 and pathological characteristics were analyzed. PcDNA-LINC01124 was transfected to upregulate LINC01124 expression in NSCLC cells, and the transfection efficiency was evaluated by the qRT-PCR. CCK8 assay, wound-healing assay, and the Transwell assay were performed to evaluate the effect of ectopic LINC01124 expression on proliferation, migration, and invasive of NSCLC cells. Results: The expression level of LINC01124 was downregulated in tumor tissues when compared with the paired normal lung tissues (P<0.05). The expression of LINC01124 was associated with patients' age and distant metastasis (P<0.05). Enforced expression of LINC01124 significantly inhibited the proliferation, migration, and invasive ability of NSCLC cells. Conclusion: The expression of LINC01124 was decreased in patients with NSCLC of older age and with those having distant metastasis. LINC01124 may inhibit cell proliferation, migration, and invasive ability. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6997214/pdf https://www.dovepress.com/getfile.php?fileID=55088 |
| Ending Page | 11736 |
| Page Count | 8 |
| Starting Page | 11729 |
| ISSN | 11786930 |
| DOI | 10.2147/OTT.S214049 |
| Journal | OncoTargets and therapy |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2020-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Oncotargets and Therapy Integrative and Complementary Medicine Linc01124 Nsclc Lncrna Long Non-coding Rna Non-small Cell Lung Cancer |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
