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lncRNA SLCO4A1-AS1 promotes growth and invasion of bladder cancer through sponging miR-335-5p to upregulate OCT4
| Content Provider | Scilit |
|---|---|
| Author | Yang, Yu Wang, Feng Huang, Hang Zhang, Yan Xie, Hui Men, Tongyi |
| Copyright Year | 2019 |
| Description | Background: Bladder cancer (BC) is among the most frequently occurring cancer types in the urinary system. In recent years, the importance of lncRNAs in BC has been acknowledged. SLCO4A1-AS1 is an oncogene in colorectal cancer. However, the role of SLCO4A1-AS1 in BC remains unknown. Materials and methods: The expression levels of SLCO4A1-AS1 in BC tissues were analyzed by qRT-PCR. The effects of SLCO4A1-AS1 knockdown on proliferation were determined by CCK8 assay. Transwell assay was used to evaluate the role of SLCO4A1-AS1 on migration and invasion. Furthermore, xenograft assay was utilized to test the effect of SLCO4A1-AS1 on BC growth in vivo. Results: SLCO4A1-AS1 expression was more upregulated in BC tissues than in adjacent normal tissues. Moreover, SLCO4A1-AS1 level was positively correlated with the advanced stage and metastasis in BC. The upregulation of SLCO4A1-AS1 indicates poor prognosis in BC patients. The knockdown of SLCO4A1-AS1 downregulated the proliferation, migration, and invasion of EJ and T24 cells in vitro. In addition, the loss of SLCO4A1-AS1 prevented BC growth in vivo. Mechanistic investigation showed that SLCO4A1-AS1 was the sponge for miR-335-5p, and miR-335-5p modulated OCT4 expression. Conclusion: High SLCO4A1-AS1 expression level was associated with the progression of BC, and SLCO4A1-AS1 promoted the malignant phenotypes of BC cells through the miR-335-5p/OCT4 axis. |
| Related Links | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6389014/pdf https://www.dovepress.com/getfile.php?fileID=48113 |
| Ending Page | 1358 |
| Page Count | 8 |
| Starting Page | 1351 |
| ISSN | 11786930 |
| DOI | 10.2147/ott.s191740 |
| Journal | OncoTargets and therapy |
| Volume Number | 12 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2019-02-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Oncotargets and Therapy Biochemistry and Molecular Biology Oncology Slco4a1-as1 Bladder Cancer Invasion Lncrna Proliferation |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pharmacology (medical) Oncology |
