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Clinical and survival outcomes of percutaneous microwave ablation for intrahepatic cholangiocarcinoma
| Content Provider | Scilit |
|---|---|
| Author | Zhang, Kai Yu, Jie Yu, Xiaoling Han, Zhiyu Cheng, Zhigang Liu, Fangyi Liang, Ping |
| Copyright Year | 2017 |
| Description | Objective: To evaluate the outcomes of percutaneous microwave ablation (MWA) and explore the prognostic factors for the survival of patients with intrahepatic cholangiocarcinoma (ICC). Methods: A total of 107 patients (age: mean 58.0 years, range 15–85 years) with 171 ICCs (maximum size ≤5 cm, tumour number per patient ≤3) who underwent MWA for ICC during January 2009 to February 2016 were selected, and their clinical and pathological data were collected and reviewed. The MWA-associated mortality, major complication rate and survival were evaluated. The prognostic factors for survival in patients with ICC were analysed with univariate and multivariate analyses. Results: The median follow-up after MWA was 20.1 months (2.8–63.5 months). There was no procedure-associated death. The overall procedure-associated major complication rate was 2.8%. The median PFS after MWA was 8.9 months; PFS rates after 6, 12, 18 and 24 months were 67.4%, 41.5%, 18.2% and 8.7%. The median OS was 28.0 months; OS rates after 1, 3 and 5 years were 93.5%, 39.6% and 7.9%. Child-Pugh class A and less tumour number were identified as factors predictive of prolonged PFS (HR for Child–Pugh class: 2.62, p = 0.001; HR for tumour number: 2.07, p = 0.002) and OS (HR for Child–Pugh class: 4.14, p < 0.001; HR for tumour number: 1.95, p = 0.024). Conclusions: Percutaneous ultrasound-guided MWA is safe and effective for ICC. Child–Pugh class A and less tumour number predict prolonged PFS and OS in patients with ICC treated by MWA. |
| Related Links | https://www.tandfonline.com/doi/pdf/10.1080/02656736.2017.1327678?needAccess=true |
| Ending Page | 297 |
| Page Count | 6 |
| Starting Page | 292 |
| ISSN | 02656736 |
| e-ISSN | 14645157 |
| DOI | 10.1080/02656736.2017.1327678 |
| Journal | International Journal of Hyperthermia |
| Issue Number | 3 |
| Volume Number | 34 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 2018-04-03 |
| Access Restriction | Open |
| Subject Keyword | Journal: International Journal of Hyperthermia Gastroenterology and Hepatology Intrahepatic Cholangiocarcinoma Microwave Ablation Percutaneous Ultrasound Outcome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Physiology Physiology (medical) Cancer Research Radiological and Ultrasound Technology |
