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Intermittent infusion of cladribine (CdA) in Previously treated patients with low-grade non-hodgkin's lymphoma
| Content Provider | Scilit |
|---|---|
| Author | Liliemarka, Jan Porwit, Anja Juliusson, Gunnar |
| Copyright Year | 1997 |
| Description | Thirty-six patients with previously treated low-grade non-Hodgkin's lymphoma (LG-NHL) were included in a phase II study between August 1990 and February 1994 and treated with 0.12 mg/kg CdA as a 2 h i.v. infusion daily X V, q 28 days up to 6 courses. Twenty-three were refractory to previous chemotherapy while 13 were relapsed. Four patients had mantle cell lymphoma, 17 follicle centre cell derived lymphoma, 7 lymphoplasmacytoid lymphomas and, 8 had small lymphocytic lymphoma. The response rate was 42%, with 5 (14%) CR and 10 (28%) PR while 6 (16%) patients progressed during treatment. The median number of delivered CdA courses was 3 (1–6) in non-responding cases and 6 (2–6) in responders. The median time to progression was 9 mo for all patients, 23 mo for CR and 16 mo for PR patients. Toxicity was sometimes severe with 3 infectious deaths (1 pneumocystis carinii pneumonia, 1 gram negative septicemia, and 1 fungal pneumonia), and 6 grade 3 or 4 infectious episodes. We conclude that responses to CdA in this group of heavily pre-treated patients is impressive. However, toxicity is considerable and the rate of opportunistic infections is worrisome. |
| Related Links | http://www.tandfonline.com/doi/pdf/10.3109/10428199709114170 |
| Ending Page | 318 |
| Page Count | 6 |
| Starting Page | 313 |
| ISSN | 10428194 |
| e-ISSN | 10292403 |
| DOI | 10.3109/10428199709114170 |
| Journal | Leukemia & Lymphoma |
| Issue Number | 3-4 |
| Volume Number | 25 |
| Language | English |
| Publisher | Informa UK Limited |
| Publisher Date | 1997-01-01 |
| Access Restriction | Open |
| Subject Keyword | Journal: Leukemia & Lymphoma Hematology Treatment Pneumonia Lymphoma Grade Cda Courses Hodgkin's |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
