NDLI: Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

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Curcumae Ameliorates Diethylnitrosamine-Induced Hepatocellular Carcinoma via Alteration of Oxidative Stress, Inflammation and Gut Microbiota

Content Provider	Scilit
Author	Zhang, Yunyan Li, Xuelian Li, Xinghua
Copyright Year	2021
Description	Background: Nonalcoholic fatty liver disease (NAFLD) increased the risk factor of hepatocellular carcinoma (HCC). NAFLD induces the hepatic-related cancer deaths mostly in middle-aged men. NAFLD enhanced the inflammatory reaction and oxidative stress in the hepatic tissue. Curcumae exhibited the anti-inflammatory and antioxidant effects. In this study, we made an attempt to scrutinize the protective effect of curcumae on obesity-induced HCC via alteration of inflammation, oxidative stress and gut microbiota. Methods: The rats used in this experiment were Wistar rats, 100 mg/kg intraperitoneal injection of diethylnitrosamine (hepatic carcinogen) was used at 2 weeks. After 6 weeks of the experimental study, the rats were randomly divided into high-fat diet (HFD) with or without curcumae-treated group rats and received the treatment for 22 weeks. Hepatic, non-hepatic, cardiac, antioxidant, pro-inflammatory and inflammatory were estimated at the end of the study. The stools of the experimental rats were collected for estimating the gut microbiota. Results: Curcumae-treated group rats exposed reduction of the hepatic nodules in hepatic tissue. Curcumae significantly (PMucispirillum and Clostridium, respectively. Conclusion: Curcumae prevents HFD-induced inflammation during the hepatic carcinoma by modulating the oxidative stress, inflammatory reaction and gut microbiota.
Related Links	https://www.dovepress.com/getfile.php?fileID=75291
Ending Page	5566
Page Count	16
Starting Page	5551
ISSN	11787031
e-ISSN	11787031
DOI	10.2147/jir.s330499
Journal	Journal of inflammation research
Volume Number	14
Language	English
Publisher	Informa UK Limited
Publisher Date	2021-10-01
Access Restriction	Open
Subject Keyword	Journal: Journal of Inflammation Research Oncology Stress Curcumae Gut Microbiota Nafld Obesity Treatment Rats Strong
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Immunology

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